2026Something Very Bad Is Going to HappenVictoria · 8 episodesShow
2026Crime 101AngieMovie
2025All's FairCheryl Goodfader · 1 episodeShow
2025Night Always ComesDoreenMovie
2024PoolmanSusan KerkovishMovie
2022Sharp StickMarilynMovie
2021AwakeDr. MurphyMovie
2021Lisey's StoryDarla Debusher · 8 episodesShow
2021The Woman in the WindowJane Russell 2Movie
2020PossessorGirderMovie
2020HuntersChava Apfelbaum · 8 episodesShow
2019Sid & JudyJudy Garland (voice)Movie
2019The Hateful EightDaisy Domergue · 4 episodesShow
2018White Boy RickAlex SnyderMovie
2018Patrick MelroseEleanor Melrose · 5 episodesShow
2018AnnihilationDr VentressMovie
2017LBJLady Bird JohnsonMovie
2017Good TimeCorey EllmanMovie
2017AtypicalElsa Gardner · 38 episodes · Producer · 38 episodesShow
2017Amityville: The AwakeningJoan WalkerMovie
2016MorganDr. Kathy GrieffMovie
2015AnomalisaLisa Hesselman (voice)Movie
2015The Hateful EightDaisy DomergueMovie
2015Welcome to MeDeb MoseleyMovie
2015Alex of VeniceMaureenMovie
2014MeKellyMovie
2014The AffairAdeline · 2 episodesShow
2014Jake SquaredSherylMovie
2014FargoLorraine Lyon · 10 episodesShow
2014Hateship LoveshipChloeMovie
2014OpenHollyMovie
2013Kill Your DarlingsNaomi GinsbergMovie
2013The Spectacular NowSara KeelyMovie
2013The MomentLeeMovie
2011RevengeKara Wallace Clarke · 7 episodesShow
2010GreenbergBeth (Beller's Party) · Story · ProducerMovie
2008Synecdoche, New YorkMariaMovie
2007Margot at the WeddingPaulineMovie
2006The Making of 'Last Exit to Brooklyn'Movie
2005Rag TaleMary Josephine 'MJ' MortonMovie
2005WeedsJill Price-Grey · 52 episodesShow
2005Easter SundayMotherMovie
2005Palindromes'Mark' AvivaMovie
2005The JacketDr. Beth LorensonMovie
2004The MachinistStevieMovie
2004ChildstarSuzanneMovie
2003In the CutPaulineMovie
2002Road to PerditionAnnie SullivanMovie
2002Hey Arnold! The MovieBridget (voice)Movie
2002Crossed OverKarla Faye TuckerMovie
2001The Man Who Wasn't ThereFemale Inmate (voice) (uncredited) · ThanksMovie
2001The QuickieLisaMovie
2001The Anniversary PartySally Nash Therrian · Director · Writer · ProducerMovie
2000O Brother, Where Art Thou?ThanksMovie
2000Skipped PartsLydia Callahan · Co-ProducerMovie
2000The King Is AliveGinaMovie
1999Mission HillEunice 'Weirdie' Eulmeyer (voice) · 1 episodeShow
1999eXistenZAllegra GellerMovie
1998HerculesTempest (voice)Show
1998Thanks of a Grateful NationTeri SmallMovie
1998The Love LetterLizzie WhitcombMovie
1998Twitch CityFaith · 1 episodeShow
1997Washington SquareCatherine SloperMovie
1997A Thousand AcresCaroline CookMovie
1997Spawn1 episodeShow
1996Bastard Out of CarolinaAnney BoatwrightMovie
1996Superman: The Animated SeriesCetea (voice) · 1 episodeShow
1996Kansas CityBlondie O'HaraMovie
1996Tracey Takes On...Paige Garland · 1 episodeShow
1995GeorgiaSadie Flood · ProducerMovie
1995Dolores ClaiborneSelena St. GeorgeMovie
1994Mrs. Parker and the Vicious CircleDorothy ParkerMovie
1994The Hudsucker ProxyAmy ArcherMovie
1993Short CutsLois KaiserMovie
1992Single White FemaleHedra 'Hedy' CarlsonMovie
1992HBO First Look1 episodeShow